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BioMEMS Applications Overview

This is a dummy description. A professional guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields 3D and 4D Printing in Biomedical Applications offers an authoritative guide to 3D and 4D printing technology in the biomedical and pharmaceutical arenas. With contributions from an international panel of academic scholars and industry experts, this book contains an overview of the topic and the most current research and innovations in pharmaceutical and biomedical applications. This important volume explores the process optimization, innovation process, engineering, and platform technology behind printed medicine.

In addition, information on biomedical developments include topics such as on shape memory polymers, 4D bio-fabrications and bone printing.

Biomedical Applications for Gas-Stabilizing Solid Cavitation Agents | Langmuir

The book covers a wealth of relevant topics including information on the potential of 3D printing for pharmaceutical drug delivery, examines a new fabrication process, bio-scaffolding, and reviews the most current trends and challenges in biofabrication for 3D and 4D bioprinting. Roberts 1. There is a long list of applications for fluorescence in biomedical and life science fields, and you can often find Avantes equipment at the forefront of new scientific frontiers.

Spectroscopy has proven to be invaluable in the fight against cancers. Autofluorescence has been shown to be far more sensitive than white light bronchoscopy in the detection of Carcinomas or dysplastic lesions, however, it also has a high rate of returning false positives.

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The team used a specially designed probe to feed through the 2. The emission peak wavelength for autofluorescence of healthy tissue was nm. Diseased tissue displayed drastically lower emission intensity at shorter wavelengths compared to healthy tissues. The combined autofluorescence imagine and optical reflectance spectroscopy significantly improved the positive predictive value compared with autofluorescence alone without sacrificing sensitivity.

Both the excitation and fluorescence wavelengths at and nm respectively are within the nm range in which blood is a primary absorber. This does create a challenge for this application, but not an insurmountable one. Researchers were confident that the modified bronchoscope with additional fibers was feasible to deploy during a standard bronchoscopy procedure.

Research over the last decade has demonstrated that conventional methods of sterilization, including thermal and chemical processes, are not sufficient to guarantee complete inactivation of all pathogenic biomolecules, especially proteins. This is a grave concern in a surgical setting where the decontamination of typically reusable medical instruments, like scalpels, can directly impact patient care. While rare, these diseases are caused by infectious proteins that transmit their incorrect folding patterns to new proteins in a manner epidemiologically similar to a viral infection.

A new method of decontamination being investigated requires a low pressure inductively coupled plasma discharge. Spectroscopic instruments are used for process control and monitoring test results. Researchers at the Swedish Defense Research Agency FOI are investigating the use of fluorescence spectroscopy as the first line of detection in bioaerosol detection systems.

Due to the dangerous nature of biological warfare agents BWAs themselves, tyrosine and tryptophan, amino acids likely to be a part of any biological agent, are used in testing in the place of these BWAs. An ideal system would be able to monitor minute particle concentrations in real time and identify compounds present with a high degree of specificity.

The system in testing with the Swedish researchers forces ambient air through a nozzle to be confined to a single particle beam and passed through the optical chamber. The use of a continuous wave blue laser at nm, received by an Avantes spectrometer, acts as a trigger. At this stage, fluorescence and scattering are analyzed. When a compound is present at pre-determined detection levels, it triggers a pulsed UV laser at nm.

The resultant laser-induced fluorescence can be further analyzed to classify individual aerosol particles. Avantes US Engineers reproduced a series of experiments conducted with samples of tryptophan, tyrosine, and bovine serum albumin recently to demonstrate our protein detection capabilities. Share Email Print. Conference Sessions At A Glance show hide.

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Bigio , Boston Univ. United States Stephen A. Boppart , Univ.

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Faber , Academisch Medisch Ctr. Program Committee continued Steven L. Jacques , Tufts Univ. United States Ofer Levi , Univ. Perelman , Harvard Univ. United States Brian W. Saturday 1 February Show All Abstracts. Session 1: Cancer detection and characterization. Wax , Duke Univ. United States. Progress in angle-resolved low-coherence interferometry for real-time detection of epithelial dysplasia Invited Paper Paper Author s : Zachary A. Chu, Adam P. Wax, Duke Univ. Subdiffuse model to extract tissue optical properties with single fiber reflectance spectroscopy, applied to esophageal cancer Paper Author s : Anouk L.

Single Fiber Reflectance spectroscopy SFR is a promising technique to detect small-scale tissue changes, e. SFR uses a single fiber to emit and collect light, and has a measurement volume in the order of hundreds of microns. We developed a new model based on physical principles to relate the measured reflectance to tissue optical properties, using approaches from Geometric Probability and deriving the first analytic solution for the diffuse contribution to SFR. We introduce a phase function parameter to describe the semi-ballistic contribution.

We will use this model to analyze in vivo measurements of the esophagus. Scatter orientation index and texture analysis of human breast tissues using multi-spectral, multi-spatial frequency structured light imaging Paper Author s : Samuel S. Rizzo, Wendy A. Wells, Dartmouth-Hitchcock Medical Ctr. United States ; Keith D. Paulsen, Brian W. Biological tissue characterization using optical imaging techniques often focus on optical property quantification, a process that relies on a diffuse or sub-diffuse light transport model.

Scattering orientation index and texture metrics quantified for human breast tissues are free of light transport assumptions and were quantified using the demodulated reflectance from wide-field structured light imaging. This work suggests that wide-field tissue diagnostics might be possible without model-based optical property quantification and instead using assumption-free scatter orientation and textural information.

Determination of the optical properties in normal and diseased tissues by novel goniometry and by 3D second harmonic generation microscopy Invited Paper Paper Author s : Paul J. We present two new methods used to determine the optical properties in ovarian cancer, idiopathic pulmonary fibrosis and osteoarthritis. The bulk optical properties are determined by a combination of on axis attenuation, goniometry, and Monte Carlo simulations. By measuring the depth dependence of the SHG emission directionality and performing Monte Carlo simulations, both the relative fibril size distribution and reduced scattering coefficient can be simultaneously determined without the need for bulk measurements.

Optical coherence tomography OCT is a high resolution and noninvasive imaging technique that can perform cellular level imaging. It measures backscattered light from microstructural features within the examined tissues. OCT typically achieves a resolution of several microns and a penetration depth of a few millimeters. In this presentation, we review the use of OCT to visualize and characterize human colorectal and ovarian tissues as well as quantitative extraction of colorectal and ovarian tissue optical properties for classification of normal and malignant process.

Session 2: Neural activity.

Biomedical Applications for Spectroscopy

Campagnola , Univ. Cerebral hemodynamics measured with diffuse optical spectroscopies to elucidate mechanisms of cognitive dysfunction after mild traumatic brain injury Invited Paper Paper Author s : Erin M. Buckley, Emory Univ.

Near infrared spectroscopy NIRS combined with diffuse correlation spectroscopy DCS enable non-invasive, bedside assessment of brain blood flow and metabolism. In numerous disease states e. Palanker, Stanford Univ.

Small cellular deformations associated with the changes of cell potential can reveal the underlying physiological activity. Phase-resolved OCT with adaptive optics in human eyes revealed rapid axial shrinkage of the cone outer segments, starting within 0. Characteristics of the rapid outer segment contraction are consistent with the early receptor potential, attributed to charge movement across the outer segment disc membranes during photoisomerization. Inverse spectroscopic optical coherence tomography to measure tissue ultrastructures and functions Invited Paper Paper Author s : Ji Yi, Boston Univ.

Blackmon, Elon Univ. United States ; Amy L. Oldenburg, The Univ. Optical coherence tomography speckle fluctuation spectroscopy OCT-SFS is a promising tool to monitor the real-time intracellular motility of 3D breast organoids in response to toxicant exposures. Here we assess the heterogeneity of their responses at the cellular and organoid level. We report significant differences depending on culture time and toxicant exposure.